Argyle will begin their EFL Trophy Southern Section Group F campaign with a home fixture against Norwich City on Tuesday, 8 September, kicking-off at 7.45pm.
Ryan Lowe's Greens will then head to Cheltenham Town for the penultimate group stage fixture on Tuesday, 6 October (7.45pm), before hosting Sky Bet League Two side Newport County at Home Park on Tuesday, 10 November, with a 7pm kick-off.
Last season, the Pilgrims fell narrowly short of qualifying for the knock-out stages of the competition, with a last-minute defeat to Chelsea eliminating the Pilgrims at the death, despite defeating Swindon Town 3-0 and Bristol Rovers on penalties, after a 1-1 draw in normal time.
Ticketing availability will be subject to government guidance. More information on options for supporters, including live streaming, will be available in due course.
EFL TROPHY FIXTURES IN FULL
Tuesday, 8 September: Norwich City (H) KO 7.45pm
Tuesday, 6 October: Cheltenham Town (A) KO 7.45pm
Tuesday, 10 November: Newport County (H) KO 7pm