Should Argyle Under-18s overcome St Ives Town in their FA Youth Cup second round clash, they will face Birmingham City in the next stage.
The Young Pilgrims face the Saints on Tuesday, November 24 in a 7pm kick-off at Home Park, after both sides won their first round proper ties by a scoreline of 6-0, against Mangotsfield United and Racing Club Warwick, respectively.
Category One Birmingham enter the competition in the third round - the stage they were eliminated at last season after losing 4-1 to Coventry City.
Blues' academy side play their league football in the U18 Premier League South and currently sit bottom of the table after nine games played.
If Argyle reach the third round, fixture information, including date, time and ticketing will be announced in due course.