Bim Pepple starts as Tom Cleverley makes three changes to the side that beat AFC Wimbledon last weekend.
Alex Hartridge and Jack MacKenzie come into defence, taking the places of injured duo Mathias Ross and Joe Edwards.
Pepple comes in for Irow and will be in search of his fifth Sky Bet League One goal of the season against Huddersfield Town.
Argyle: 1 Murphy Cooper, 3 Jack MacKenzie, 7 Harvey White, 9 Will Evans, 11 Ronan Curtis, 15 Alex Mitchell, 17 Caleb Watts, 22 Alex Hartridge, 23 Bradley Ibrahim, 27 Bim Pepple, 45 Wes Harding (capt). Substitutes: 21 James Storer, 5 Julio Pleguezuelo, 10 Xavier Amaechi, 14 Oliver Irow, 19 Tyreeq Bakinson, 29 Matty Sorinola, 42 Jared Rendle.
Huddersfield Town: 1 Matthew Young, 5 Joe Low, 8 Archie Collins, 9 Joe Taylor, 15 Ibane Bowat, 19 Bali Mumba, 20 Cameron Humphreys (capt), 22 Ilias Bronkhorst, 23 Sean Roughan, 25 Bojan Radulovic, 30 Derensili Sanches Fernandes. Substitutes: 31 Jak Alnwick, 2 Lasse Sorensen, 7 Lynden Gooch, 10 Marcus Harness, 11 Ashley Fletcher, 14 Ethan Brierley, 34 Samson Tovide.
