Tom Cleverley names three changes to the side that lost against Burton Albion at Home Park last weekend.
Club captain Joe Edwards makes his first league start of the season, taking the place of Matty Sorinola at full-back. Bradley Ibrahim comes in for Tyreeq Bakinson in midfield; the latter is ineligible to play as he is on loan at Argyle from today's opponents. Finally, Mathias Ross starts in defence after Julio Pleguezuelo was ruled out with a knee injury sustained last weekend against Burton.
There are places on the bench for 17-year-old's Seb Campbell and Jared Rendle. If Rendle is brought on at any point this afternoon, he will be making his Sky Bet League One debut.
Leyton Orient: 1 Nathan Baxter, 2 Fin Stevens, 5 Joseph Olowu, 6 Will Forrester, 8 Idris El Mizouni (capt), 9 Jaze Kabia, 20 Alex Gilbert, 22 Yusuf Akhamrich, 25 Charlie Wellens, 27 Tony Springett, 34 Philip Chinedu. Substitutes: 33 Killian Cahill (GK), 10 Aaron Connolly, 12 Alfie Gilchrist, 14 Isaac Hayden, 17 Armando Dobra, 18 Dane Scarlett, 44 Theo Archibald.
Argyle: 1 Murphy Cooper, 2 Mathias Ross, 7 Harvey White, 8 Joe Edwards (capt), 9 Will Evans, 11 Ronan Curtis, 14 Oliver Irow, 15 Alex Mitchell, 23 Bradley Ibrahim, 27 Bim Pepple, 45 Wes Harding. Substitutes: 21 James Storer (GK), 3 Jack MacKenzie, 10 Xavier Amaechi, 17 Caleb Watts, 29 Matty Sorinola, 38 Seb Campbell, 42 Jared Rendle.
