Tom Cleverley makes wholesale changes to the side that beat Leyton Orient at BetWright Stadium on Saturday.
Just Mathias Ross remains from the team that won in East London, other than that there are changes all across the pitch.
Despite being out on loan at Torquay United, both Caleb Roberts and Tegan Finn are able to feature for Argyle in the Jersey Mike's Trophy tonight, and start.
Newport County: 33 Shaun McDonald, 2 Cameron Evans, 7 Kieron Evans, 8 Matt Smith, 12 Joe Thomas, 17 Alfie Merritt, 18 Aaron Lewis, 19 Ged Garner, 20 Yahya Bamba, 34 Dan Sassi, 40 Cole Jarvis. Substitutes: 1 Jordan Wright (GK), 5 Lee Jenkins, 10 Harrison Biggins, 16 Matty Jacob, 23 Michael Adu-Poku, 24 Matt Dibley-Dias, 27 Christian Doidge.
Argyle: 21 James Storer, 2 Mathias Ross (capt), 3 Jack MacKenzie, 10 Xavier Amaechi, 17 Caleb Watts, 19 Tyreeq Bakinson, 24 Caleb Roberts, 26 Tegan Finn, 29 Matty Sorinola, 38 Seb Campbell, 42 Jared Rendle. Substitutes: 1 Murphy Cooper, 7 Harvey White, 11 Ronan Curtis, 14 Oliver Irow, 23 Bradley Ibrahim, 27 Bim Pepple, 45 Wes Harding.
