There was more away-day delight for Argyle, who scored three on the road to beat Wigan Athletic comfortably at The Brick Community Stadium.
Bim Pepple netted a quick-fire brace just before half-time to give the Greens the advantage, before Caleb Watts sealed the result midway through the second period.
Tom Cleverley opted to make two changes to the side that beat Doncaster Rovers at Home Park just three days previously.
Injury meant that both Matty Sorinola and Wes Harding dropped out and were replaced by Herbie Kane and Owen Dale, respectively.
Luca Ashby-Hammond kept his place in goal; the defence ahead of him consisted of Joe Edwards, Mathias Ross, Alex Mitchell, and Jack MacKenzie, from right to left.
Malachi Boateng held down the centre of the park and was accompanied by Herbie Kane, the midfielder making his first start in nearly a month.
Ronan Curtis started on the right flank, with Owen Dale playing the same role but on the left.
Watts played just behind and in support of Pepple; the Canadian had netted nine goals in his last 12 games coming into this one.
It was a pretty uneventful start to the game for both sides; neither team created any meaningful chances that tested either goalkeeper.
Argyle had the better of the possession, but struggled to break down the resolute back three of Jason Kerr, Will Aimson, and Luke Robinson; this would be their challenge.
Mitchell flashed a header narrowly wide of the post following an excellent Herbie Kane set-piece delivery, a chance the defender would probably have expected himself to do better from.
It was a near disaster for the Greens when Joe Taylor stole the ball from Curtis following a short free kick on the left. With the majority of the Argyle players still inside the Wigan penalty area, Taylor bombed forward on the break and blasted an effort just over the crossbar.
The Pilgrims kept the pressure on. Watts was a key component in the majority of Argyle’s attacks and looked to be the player most likely to create something for the Greens.
It was that man who sprayed an impressive ball in behind the Wigan backline that Pepple latched onto. Fortunately for the hosts, Sam Tickle was quick off his line to collect it before Pepple could take aim.
Argyle’s form man then found a goal, seemingly from nothing, towards the end of the first period. Curtis swung in a free kick that just evaded the crowd in the penalty area and looked relatively easy for Tickle to collect.
However, the goalkeeper made a rare blunder and dropped his attempted catch right into the path of Pepple, who made no error from just yards out to make it 1-0.
Things got even better for Argyle when they made it two in as many minutes, Pepple the scorer once again.
This time, the credit must go to the play that came before the strike. Edwards and Curtis combined well down the right, attracting at least three Wigan players and therefore making space slightly infield for Boateng.
The midfielder ventured forward and cut the ball back to Pepple, who was unmarked, just as he breached the penalty area. It was another poacher’s finish for the Canadian, who netted a quickfire double for both himself and the team, just before the break.
Wigan looked deflated, as you might expect, with Argyle firmly in control and looking likely to further add to their tally as they headed into half-time.
The task at hand now was to guard against complacency and keep the hosts at bay, who were likely to come out swinging after the interval.
Wigan did look better when they came back out; they nearly profited from a well-worked corner, but a timely Argyle intervention denied Christian Saydee an effort on goal.
Half-time substitute Harrison Bettoni forced a strong save from Ashby-Hammond when he curled a free-kick well over the wall and towards the side netting.
It felt as though Wigan were building some momentum, something the Greens needed to stamp out before it resulted in a goal.
There were big penalty calls from the hosts when Bettoni picked out Taylor inside the penalty area; his effort on goal seemed to strike the arm of MacKenzie, prompting calls for a spot kick from the majority inside The Brick Community Stadium, but referee Scott Oldham did not agree.
The Pilgrims had the chance to add insult to injury when, moments later, Curtis’s corner was met by Dale on the edge of the six-yard box. His header was not one that really threatened Tickle; it was easy enough for Wigan’s number one to collect.
When Argyle’s next chance came, they did not blink, making it 3-0. Boateng and Edwards combined well again, as they had done on several occasions, the former sending a low cross towards the back post.
Fraser Murray’s botched intervention crashed against his own post, and the resulting clearance only made it as far as Boateng on the edge of the box. The midfielder slid a pass square to Watts, who rifled an effort beyond the outstretched glove of Tickle and into the bottom-left corner.
Wigan nearly had a consolation goal when Caylan Vickers darted into the Argyle penalty area and poked the ball through to Taylor, who was in space. The striker lashed his strike against the crossbar, an effort that probably summed up the hosts’ evening.
There was a league debut for youngster Seb Campbell at the end of the game; he took the place of Watts with five minutes left on the clock.
The Pilgrims were able to see the remaining minutes out with relative ease.Wigan knew they were a beaten side, and Argyle did what they had to do in order to seal the result.
It was an important midweek victory for Cleverley’s side, who managed to gain ground on some of those around them and make it two consecutive wins coming into a crucial period of the season.
On Saturday, the Greens travel to Reading in what promises to be a blockbuster clash in Berkshire.
Wigan Athletic: 1 Sam Tickle, 4 Will Aimson, 6 Jensen Weir, 7 Fraser Murray(21 Raphael Borges Rodrigues, 83), 9 Christian Saydee (25 Caylan Vickers, 69), 10 Joe Taylor, 15 Jason Kerr (capt), 17 Matt Smith (43 Harrison Bettoni,HT), 19 Luke Robinson (45 Llyton Chapman, 69), 20 Callum McManaman (44 Joseph Hungbo, HT), 33 Owen Moxon. Substitutes: 30 Toby Savin (gk), 28 Leo Graham.
Argyle: 21 Luca Ashby-Hammond, 2 Mathias Ross, 3 Jack MacKenzie (7 Jamie Paterson, 78), 8 Joe Edwards (capt), 15 Alex Mitchell, 17 Caleb Watts(41 Seb Campbell, 85), 19 Malachi Boateng, 20 Herbie Kane (4 Brendan Wiredu, 74), 27 Bim Pepple (18 Owen Oseni, 86), 28 Ronan Curtis (10 Xavier Amaechi, 78), 35 Owen Dale. Substitutes: 13 Zak Baker (gk), 40 Joe Mwaro.
Goals: Pepple 38, 40, Watts 71
Booked: Curtis 53, Watts 64
Referee: Scott Oldham
Attendance: 8,055
